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Article

Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.

The EMBO journal - 1 Dec 1991

Shemshedini L, Knauthe R, Sassone-Corsi P, Pornon A, Gronemeyer H

Abstract excerpt

We investigated the effect of c-Fos and/or c-Jun co-expression on transcription activation by the progesterone (PR), glucocorticoid (GR) or androgen (AR) receptors using three different reporter genes and four different cell lines. We found that c-Fos could only inhibit, while c-Jun could either inhibit or further stimulate receptor-induced transcription. All these effects were receptor, promoter, and cell type...

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Identifiers

PMID: 1935903
DOI: 10.1002/j.1460-2075.1991.tb04953.x
PMCID: PMC453121

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Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.PMID 1935903Read ↗

Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site.Semantic proximity Read ↗

Regulation of c-Fos gene transcription by stimulus-responsive protein kinases.Semantic proximity Read ↗

Both Jun and Fos contribute to transcription activation by the heterodimer.Semantic proximity Read ↗

Mutual regulation of c-Jun and ATF2 by transcriptional activation and subcellular localization.Semantic proximity Read ↗

Interference of pathway specific transcription factors.Semantic proximity Read ↗

Phosphorylation of ATF2 and interaction with NFY induces c-Jun in the gonadotropeSemantic proximity Read ↗

Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.Semantic proximity Read ↗

Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor- BSemantic proximity Read ↗

Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB.Semantic proximity Read ↗

Crosstalk of CREB and Fos/Jun on a single cis-element: transcriptional repression of the steroidogenic acute regulatory protein geneSemantic proximity Read ↗

Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR).Semantic proximity Read ↗

The nuclear receptor coactivators p300/CBP/cointegrator-associated protein (p/CIP) and transcription intermediary factor 2 (TIF2) differentially regulate PKA-stimulated transcriptional activity of steroidogenic factor 1.Semantic proximity Read ↗

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