Article
Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.
The EMBO journal - 1 Dec 1991
Shemshedini L, Knauthe R, Sassone-Corsi P, Pornon A, Gronemeyer H
Abstract excerpt
We investigated the effect of c-Fos and/or c-Jun co-expression on transcription activation by the progesterone (PR), glucocorticoid (GR) or androgen (AR) receptors using three different reporter genes and four different cell lines. We found that c-Fos could only inhibit, while c-Jun could either...
Topics
- Base Sequence
- Chloramphenicol O-Acetyltransferase
- Colforsin
- DNA
- HeLa Cells
- Humans
- Leucine Zippers
- Molecular Sequence Data
- Mutation
- Plasmids
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun
- Receptors, Androgen
- Receptors, Glucocorticoid
- Receptors, Progesterone
- Receptors, Steroid
- Transcription, Genetic