Article

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

2025-04-18

Abstract excerpt

<h4>Summary</h4> P53 prevents DNA damage by inducing repair processes, cell cycle arrest or apoptosis. P53 loss leads to replication stress and genomic instability, yet the mechanisms underlying these effects and their contribution to catastrophic genomic events such as chromothripsis remain poorly understood. Using patient-derived fibroblasts with germline p53 variants, that spontaneously undergo chromothripsis,...

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Literature Corpus work: 7a255754-45bb-5b40-917a-aa378bc652f6
DOI: 10.1101/2025.04.17.649416

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