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Article

Differential role of the proline-rich domain of nuclear factor 1-C splice variants in DNA binding and transactivation.

The Journal of biological chemistry - 10 May 2002

Prado Felix, Vicent Guillermo, Cardalda Carina, Beato Miguel

Abstract excerpt

We have addressed the functional significance of the existence of several natural splice variants of NF1-C* differing in their COOH-terminal proline-rich transactivation domain (PRD) by studying their specific DNA binding and transactivation in the yeast Saccharomyces cerevisiae. These parameters yielded the intrinsic transactivation potential (ITP), defined as the activation observed with equal amounts of DNA...

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PMID: 11861650
DOI: 10.1074/jbc.M200418200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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