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Article

O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions.

Molecular and cellular biology - 1 Nov 1997

Roos M D, Su K, Baker J R, Kudlow J E

Abstract excerpt

The O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins is dynamic and abundant in the nucleus and cytosol. Several transcription factors, including Sp1, have been shown to contain this modification; however, the functional role of O-GlcNAc in these proteins has not been determined. In this paper we describe the use of the previously characterized glutamine-rich transactivation domain of Sp1 (B-c) as...

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Identifiers

PMID: 9343410
DOI: 10.1128/MCB.17.11.6472
PMCID: PMC232500

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