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Article

Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor.

Molecular and cellular biology - 1 Feb 1997

Almlöf T, Gustafsson J A, Wright A P

Abstract excerpt

We have performed a mutagenesis analysis of the 58-amino-acid tau1-core peptide, which represents the core transactivation activity of the tau1 transactivation domain from the glucocorticoid receptor. Mutants with altered activity were identified by phenotypic screening in the yeast Saccharomyces cerevisiae. Most mutants with reduced activity had substitutions of hydrophobic amino acids. Most single-substitution...

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Identifiers

PMID: 9001247
DOI: 10.1128/MCB.17.2.934
PMCID: PMC231819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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