Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor.

doi:10.1128/MCB.17.2.934

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Article

Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor.

Molecular and cellular biology - 1 Feb 1997

Almlöf T, Gustafsson J A, Wright A P

Abstract excerpt

We have performed a mutagenesis analysis of the 58-amino-acid tau1-core peptide, which represents the core transactivation activity of the tau1 transactivation domain from the glucocorticoid receptor. Mutants with altered activity were identified by phenotypic screening in the yeast Saccharomyces...

Topics

Alanine
Amino Acid Sequence
Amino Acids
Animals
COS Cells
Humans
Molecular Sequence Data
Mutation
Protein Structure, Secondary
Receptors, Glucocorticoid
Recombinant Fusion Proteins
Saccharomyces cerevisiae
Trans-Activators

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