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Article

Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1.

Genetics - 1 Sept 1998

Lackner M R, Kim S K

Abstract excerpt

The Caenorhabditis elegans mpk-1 gene encodes a MAP kinase protein that plays an important role in Ras-mediated induction of vulval cell fates. We show that mutations that eliminate mpk-1 activity result in a highly penetrant, vulvaless phenotype. A double mutant containing a gain-of-function mpk-1 mutation and a gain-of-function mek mutation (MEK phosphorylates and activates MPK-1) exhibits a multivulva...

Topics

Alleles
Animals
Base Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Differentiation
DNA Primers
Mitogen-Activated Protein Kinase 1
Phenotype
Phosphorylation
Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Transcription Factors

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9725833
DOI: 10.1093/genetics/150.1.103
PMCID: PMC1460334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9725833-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1.PMID 9725833Read ↗

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.Semantic proximity Read ↗

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The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.Semantic proximity Read ↗

lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans.Semantic proximity Read ↗

Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.Semantic proximity Read ↗

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.Semantic proximity Read ↗

Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans.Semantic proximity Read ↗

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lin-25, a gene required for vulval induction in Caenorhabditis elegans.Semantic proximity Read ↗

A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated Ras.Semantic proximity Read ↗

C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.Semantic proximity Read ↗

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