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Article

Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation.

Cell death and differentiation - 1 May 2015

O'Reilly L A, Hughes P, Lin A, Waring P, Siebenlist U, Jain R, Gray D H D, Gerondakis S, Strasser A

Abstract excerpt

FASL/FAS signaling imposes a critical barrier against autoimmune disease and lymphadenopathy. Mutant mice unable to produce membrane-bound FASL (FasL(Δm/Δm)), a prerequisite for FAS-induced apoptosis, develop lymphadenopathy and systemic autoimmune disease with immune complex-mediated glomerulonephritis. Prior to disease onset, FasL(Δm/Δm) mice contain abnormally high numbers of leukocytes displaying activated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25361085
DOI: 10.1038/cdd.2014.168
PMCID: PMC4392074

Genes

REL
FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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