Article
The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice.
European journal of immunology - 1 Dec 1994
Mariani S M, Matiba B, Armandola E A, Krammer P H
Abstract excerpt
APO-1/Fas (CD95) is a transmembrane receptor that transduces apoptotic signals within various cells including T and B cells. The APO-1 gene was found to be defective in lpr mice. In these mice insertion of a retrotransposon gives rise to transcription of an abnormal mRNA and only a fraction of wi...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Antigens, Surface
- Apoptosis
- Base Sequence
- CD3 Complex
- DNA Primers
- Flow Cytometry
- Gene Expression
- Leukocyte Common Antigens
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Molecular Sequence Data
- RNA, Messenger
- T-Lymphocytes