Article
Not infrequent K-ras mutations in depressed-type early colorectal carcinomas larger than 10 mm.
Japanese journal of cancer research : Gann - 1 Feb 2002
Kazama Shinsuke, Ajioka Yoichi, Watanabe Hidenobu, Watanabe Toshiaki, Nagawa Hirokazu
Abstract excerpt
The aim of this study was to elucidate whether K-ras (codons 12 and 13) mutations occur in depressed-type early colorectal carcinomas (DECas) larger than 10 mm in size. Thirty-four cases of DECas including 27 larger than 10 mm were examined for K-ras mutations by means of microdissection, PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism), and direct sequencing. Although K-ras mutation...
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