Article
Testing causal hypotheses in multivariate linkage analysis of quantitative traits: general formulation and application to sibpair data.
Genetic epidemiology - 1 Jan 1998
Todorov A A, Vogler G P, Gu C, Province M A, Li Z, Heath A C, Rao D C
Abstract excerpt
We provide a general framework for the development of model-free methods for the linkage analysis of multivariate phenotypic data. It is possible within this framework to test both for linkage of a set of phenotypes to one or more markers and for the presence of structural relations among the phe...
Topics
- Chromosome Mapping
- Genetic Linkage
- Humans
- Matched-Pair Analysis
- Models, Genetic
- Models, Statistical
- Multivariate Analysis
- Phenotype
- Quantitative Trait, Heritable
- Statistics, Nonparametric