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Article

Dominant negative alpha-subunit of FTase inhibits effects of insulin and IGF-I in MCF-7 cells.

Biochemical and biophysical research communications - 1 Mar 2002

Solomon Curtis Scott, Goalstone Marc Lee

Abstract excerpt

We recently designed a dominant negative (DN) farnesyltransferase (FTase)/geranyl-gerahyltransferase I (GGTase I) alpha-subunit that when expressed in vascular smooth muscle cells decreased insulin-stimulated phosphorylation of FTase, FTase activity, amounts of farnesylated p21Ras, DNA synthesis, and cell migration. Currently, we explored the inhibitory effects of DN FTase/GGTase I alpha-subunit in MCF-7 cells on...

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Share to Alkyl and Aryl Transferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

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Source

Identifiers

PMID: 11855811
DOI: 10.1006/bbrc.2002.6471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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