Article
Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization.
The Journal of biological chemistry - 13 May 2011
Siddals Kirk W, Allen Justine, Sinha Smeeta, Canfield Ann E, Kalra Philip A, Gibson J Martin
Abstract excerpt
Vascular calcification is strongly linked with increased morbidity and mortality from cardiovascular disease. Vascular calcification is an active cell-mediated process that involves the differentiation of vascular smooth muscle cells (VSMCs) to an osteoblast-like phenotype. Several inhibitors of this process have been identified, including insulin-like growth factor-I (IGF-I). In this study, we examined the role...
Topics
- 1-Deoxynojirimycin
- Animals
- Antiviral Agents
- Aorta
- Cattle
- Cell Differentiation
- Glycerophosphates
- Glycosylation
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors