Article
Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2007
Li Ming, He Zhiwei, Ermakova Svetlana, Zheng Duo, Tang Faqing, Cho Yong-Yeon, Zhu Feng, Ma Wei-Ya, Sham Yuk, Rogozin Evgeny A, Bode Ann M, Cao Ya, Dong Zigang
Abstract excerpt
Insulin-like growth factor-I receptor (IGF-IR) has been implicated in cancer pathophysiology. Furthermore, impairment of IGF-IR signaling in various cancer cell lines caused inhibition of the transformed phenotype as determined by the inhibition of colony formation in soft agar and the inhibition of tumor formation in athymic nude mice. Thus, the IGF-IR might be an attractive target for cancer prevention. We...
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