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Article

Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor.

Cancer chemotherapy and pharmacology - 1 Jan 2011

Appels Natalie M G M, Bolijn Maria J, van Eijndhoven Maria A J, Stephens Trevor C, Beijnen Jos H, Schellens Jan H M

Abstract excerpt

PURPOSE: AZD3409 is a novel DPTI that has potent activity against both FTase and GGTase-1. The in vitro inhibition profile of AZD3409 was characterized using three different cell lines: mouse embryogenic fibroblasts, transfected with H-Ras(V12) (MEF), A549 cells (Ki4B-Ras mutation) and MCF-7 cell...

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Share to Alkyl and Aryl Transferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20229082
DOI: 10.1007/s00280-010-1300-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20229082-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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