Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity.

European journal of pharmacology - 15 Mar 2009

Chin Chen-Ni, Dallas-Yang Qing, Liu Franklin, Ho Thu, Ellsworth Kenneth, Fischer Paul, Natasha Tajneen, Ireland Cheryl, Lu Ping, Li Cai, Wang I-Ming, Strohl William, Berger Joel P, An Zhiqiang, Zhang Bei B, Jiang Guoqiang

Abstract excerpt

Plasma cell membrane glycoprotein-1 or ectonucleotide pyrophosphatase/phosphodiesterase (PC-1/ENPP1) has been shown to inhibit insulin signaling, and its genetic polymorphism or increased expression is associated with type 2 diabetes in humans. Therefore, PC-1 inhibition represents a potential strategy in treating diabetes. Since patients with phosphodiesterase/pyrophosphatase deficient PC-1 manifest abnormal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Phosphoric Diester Hydrolases

Share to Protein Transport

Share to Pyrophosphatases

Share to Receptor, Insulin

Share to Transfection

Source

Identifiers

PMID: 19374858
DOI: 10.1016/j.ejphar.2009.01.016

Genes

ENPP1
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity.PMID 19374858Read ↗

The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.Semantic proximity Read ↗

The role of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 in diabetic nephropathy.Semantic proximity Read ↗

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.Semantic proximity Read ↗

Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes.Semantic proximity Read ↗

Protein phosphatase-1α interacts with and dephosphorylates polycystin-1.Semantic proximity Read ↗

Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.Semantic proximity Read ↗

Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity.Semantic proximity Read ↗

Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1.Semantic proximity Read ↗

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.Semantic proximity Read ↗

The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.Semantic proximity Read ↗

Polycystin-1 Inhibits Cell Proliferation through Phosphatase PP2A/B56α.Semantic proximity Read ↗

Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma cell membrane glycoprotein–1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.