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Article

Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.

Endocrinology - 1 Jul 2012

Müller Isabelle, Rössler Oliver G, Wittig Christine, Menger Michael D, Thiel Gerald

Abstract excerpt

Expression of early growth response protein (Egr)-1, a protein of the Egr family of zinc finger transcription factors, is stimulated in glucose-treated pancreatic β-cells and insulinoma cells. The purpose of this study was to elucidate the role of Egr transcription factors in pancreatic β-cells in vivo. To overcome the problem associated with redundancy of functions between Egr proteins, conditional transgenic...

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PMID: 22597533
DOI: 10.1210/en.2012-1064

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Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.PMID 22597533Read ↗

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