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Article

Thermodynamic and kinetic insights into stop codon recognition by release factor 1.

PloS one - 1 Jan 2014

Trappl Krista, Mathew Merrill A, Joseph Simpson

Abstract excerpt

Stop codon recognition is a crucial event during translation termination and is performed by class I release factors (RF1 and RF2 in bacterial cells). Recent crystal structures showed that stop codon recognition is achieved mainly through a network of hydrogen bonds and stacking interactions between the stop codon and conserved residues in domain II of RF1/RF2. Additionally, previous studies suggested that...

Topics

Codon, Terminator
Escherichia coli
Escherichia coli Proteins
Hydrolysis
Kinetics
Models, Molecular
Mutation
Peptide Termination Factors
Ribosomes
Thermodynamics

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Identifiers

PMID: 24699820
DOI: 10.1371/journal.pone.0094058
PMCID: PMC3974865

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