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Article

Metabolic stress promotes stop-codon readthrough and phenotypic heterogeneity.

Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2020

Zhang Hong, Lyu Zhihui, Fan Yongqiang, Evans Christopher R, Barber Karl W, Banerjee Kinshuk, Igoshin Oleg A, Rinehart Jesse, Ling Jiqiang

Abstract excerpt

Accurate protein synthesis is a tightly controlled biological process with multiple quality control steps safeguarded by aminoacyl-transfer RNA (tRNA) synthetases and the ribosome. Reduced translational accuracy leads to various physiological changes in both prokaryotes and eukaryotes. Termination of translation is signaled by stop codons and catalyzed by release factors. Occasionally, stop codons can be...

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Identifiers

PMID: 32839318
DOI: 10.1073/pnas.2013543117
PMCID: PMC7486758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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