Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease.

doi:10.1161/ATVBAHA.110.208900

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Article

Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2010

Ibrahim Salam, Tetruashvily Mazell, Frey Alex J, Wilson Stephen J, Stitham Jeremiah, Hwa John, Smyth Emer M

Abstract excerpt

OBJECTIVE: Prostacyclin and thromboxane mediate opposing cardiovascular effects through their receptors, the prostacyclin receptor (IP) and thromboxane receptor (TP). Individuals heterozygous for an IP variant, IP(R212C), displayed exaggerated loss of platelet IP responsiveness and accelerated cardiovascular disease. We examined association of IP(R212C) into homo- and heterodimeric receptor complexes and the...

Topics

Cardiovascular Diseases
Cell Line
Cyclic AMP
Dimerization
Dose-Response Relationship, Drug
Endoplasmic Reticulum
Epoprostenol
Fluorescence Resonance Energy Transfer
Genotype
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Humans

Inositol Phosphates

Mutation

Phenotype

Receptors, Epoprostenol

Receptors, Prostaglandin

Receptors, Thromboxane A2, Prostaglandin H2

Source

Open in PubMed Open full text

Identifiers

PMID: 20522800
DOI: 10.1161/ATVBAHA.110.208900
PMCID: PMC2924460

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