Article
Higher blood pressure in elderly hypertensive females, with increased arterial stiffness and blood pressure in females with the Fibrillin-1 2/3 genotype.
BMC cardiovascular disorders - 17 Apr 2020
Åström Malm Ida, Alehagen Urban, Blomstrand Peter, Dahlström Ulf, De Basso Rachel
Abstract excerpt
BACKGROUND: Elderly patients have a relatively high cardiovascular risk due to increased arterial stiffness, elevated blood pressure and decreased amounts of elastin in the arteries. The composition of the media layer in the arterial wall, comprising elastin, collagen, smooth muscle cells, proteoglycans, fibronectin and fibrillin-1, influences its mechanical properties. Mutations in the fibrillin-1 gene leads to...
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