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Article

Genotype impacts survival in Marfan syndrome.

European heart journal - 14 Nov 2016

Franken Romy, Groenink Maarten, de Waard Vivian, Feenstra Helena M A, Scholte Arthur J, van den Berg Maarten P, Pals Gerard, Zwinderman Aeilko H, Timmermans Janneke, Mulder Barbara J M

Abstract excerpt

AIMS: The aorta in Marfan syndrome (MFS) patients is variably affected. We investigated the assumed genotype-effect on protein production as a risk factor for a severe aortic phenotype in adult MFS patients. METHODS AND RESULTS: We collected clinical and genetic data from all 570 adults with MFS who had been included in the Dutch CONgenital CORvitia registry since the start in 2001. Mean age was 36.5 ± 13.5 years...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26787436
DOI: 10.1093/eurheartj/ehv739

Genes

FBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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