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Article

Mutator bacteria as a risk factor in treatment of infectious diseases.

Antimicrobial agents and chemotherapy - 1 Mar 2002

Giraud Antoine, Matic Ivan, Radman Miroslav, Fons Michel, Taddei François

Abstract excerpt

We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator alleles' high mutation rates, the initial treatment failure increases the probability of failures in subsequent treatments with other drugs.

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Identifiers

PMID: 11850274
DOI: 10.1128/AAC.46.3.863-865.2002
PMCID: PMC127494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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