Article
The role of mutators in the emergence of antibiotic-resistant bacteria.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jun 2003
Chopra Ian, O'Neill Alexander J, Miller Keith
Abstract excerpt
Bacteria contain a number of error prevention and error correction systems that maintain genome stability. However, strains exhibiting elevated mutation frequencies have recently been reported amongst natural populations of pathogenic Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa, Neisseria meningitidis, Helicobacter pylori and Streptococcus pneumoniae. The majority of naturally occurring, strong...
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