Article
Hypermutability and compensatory adaptation in antibiotic-resistant bacteria.
The American naturalist - 1 Sept 2010
Perron Gabriel G, Hall Alex R, Buckling Angus
Abstract excerpt
Hypermutable (mutator) bacteria have been associated with the emergence of antibiotic resistance. A simple yet untested prediction is that mutator bacteria are able to compensate more quickly for pleiotropic fitness costs often associated with resistance, resulting in the maintenance of resistance in the absence of antibiotic selection. By using experimental populations of a wild-type and a mutator genotype of...
Topics
- Adaptation, Physiological
- Anti-Bacterial Agents
- Drug Resistance, Bacterial
- Genotype
- Mutation
- Pseudomonas aeruginosa
- Rifampin
- Selection, Genetic
- Time Factors