Article
Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed.
Cancer letters - 8 Apr 2002
Zeng Guichao, Gao Luoyi, Suetake Keiji, Joshi Ratan Mani, Yu Robert K
Abstract excerpt
Alteration in ganglioside composition in F-11 cells by suppression of GD3-synthase gene expression resulted in greatly reduced tumor growth and metastasis when the cells were injected into nude mice. To identify genes whose expression is correlated with the decreased level of ganglioside GD3, we analyzed gene expression profiles of the GD3-suppressed F-11 cells and the control F-11 cells using DNA microarrays. We...
Topics
- Animals
- DNA Primers
- DNA, Antisense
- Down-Regulation
- Gangliosides
- Gene Expression Profiling
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Immunoblotting
- Neoplasm Metastasis
- Neuroblastoma
- Oligonucleotide Array Sequence Analysis