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Subtraction hybridization identifies a transformation progression-associated gene <i>PEG</i> -3 with sequence homology to a growth arrest and DNA damage-inducible gene

19 Aug 1997

Abstract excerpt

Cancer is a progressive multigenic disorder characterized by defined changes in the transformed phenotype that culminates in metastatic disease. Determining the molecular basis of progression should lead to new opportunities for improved diagnostic and therapeutic modalities. Through the use of subtraction hybridization, a gene associated with transformation progression in virus- and oncogene-transformed rat...

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PMID: 9256446
DOI: 10.1073/pnas.94.17.9125

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