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Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model

18 Jun 2021

Abstract excerpt

High expression of gangliosides GD3 and GD2 is observed in human gliomas. The functions of GD3 and GD2 in malignant properties have been reported in glioma cells in vitro, but those functions have not yet been investigated in vivo. In this study, we showed that deficiency of GD3 synthase (GD3S, St8sia1) attenuated glioma progression and clinical and pathological features in a platelet-derived growth factor...

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PMID: 34145699
DOI: 10.1111/cas.15032

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