Article
Manganese superoxide dismutase genotypes and asbestos-associated pulmonary disorders.
Cancer letters - 8 Apr 2002
Hirvonen Ari, Tuimala Jarno, Ollikainen Tiina, Linnainmaa Kaija, Kinnula Vuokko
Abstract excerpt
Manganese superoxide dismutase (MnSOD) activity is highly elevated in the biopsies of human asbestos-associated malignant mesothelioma. We therefore examined if polymorphism in the mitochondrial targeting sequence of the MnSOD gene modified individual susceptibility to this malignancy or related asbestos-associated pulmonary disorders. The study population consisted of 124 male Finnish asbestos insulators who...
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