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Article

A combinatorial library of indinavir analogues and its in vitro and in vivo studies.

Bioorganic & medicinal chemistry letters - 25 Feb 2002

Cheng Yuan, Rano Thomas A, Huening Tracy T, Zhang Fengqi, Lu Zhijian, Schleif William A, Gabryelski Lori, Olsen David B, Stahlhut Mark, Kuo Lawrence C, Lin Jiunn H, Xu Xin, Jin Lixia, Olah Timothy V, McLoughlin Debra A, King Rick C, Chapman Kevin T, Tata James R

Abstract excerpt

A combinatorial library of 300HIV protease inhibitors has been synthesized. The library was screened against recombinant wild-type and mutant HIV-1 protease enzymes. The pharmacokinetics of the library was evaluated by dosing in dogs. Compounds that are notably more potent than indinavir and have favorable pharmacokinetic properties were identified.

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Identifiers

PMID: 11844665
DOI: 10.1016/s0960-894x(01)00824-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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