Article
Synthesis, biological evaluation and in silico modeling of novel integrase strand transfer inhibitors (INSTIs).
European journal of medicinal chemistry - 1 Mar 2020
Ivashchenko Andrey A, Ivanenkov Yan A, Koryakova Angela G, Karapetian Ruben N, Mitkin Oleg D, Aladinskiy Vladimir A, Kravchenko Dmitry V, Savchuk Nikolai P, Ivashchenko Alexander V
Abstract excerpt
Although a relatively wide range of therapeutic options is currently available for the treatment of HIV/AIDS, it is still among the most serious and virulent diseases and is associated with a high mortality rate. Integrase strand transfer inhibitors (INSTIs), e.g., FDA-approved dolutegravir (DTG), bictegravir (BIC) and cabotegravir (CAB), have recently been included in standard highly active antiretroviral...
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