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Article

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.

Journal of medicinal chemistry - 8 May 2003

Smith Amos B, Cantin Louis-David, Pasternak Alexander, Guise-Zawacki Lisa, Yao Wenquin, Charnley Adam K, Barbosa Joseph, Sprengeler Paul A, Hirschmann Ralph, Munshi Sanjeev, Olsen David B, Schleif William A, Kuo Lawrence C

Abstract excerpt

The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors [(-)-6, (-)-7, (-)-23, (+)-24] based upon the 3,5,5-trisubstituted pyrrolin-4-one scaffold is described. Use of a monopyrrolinone scaffold leads to inhibitors with improved cellular transport properties rela...

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Identifiers

PMID: 12723947
DOI: 10.1021/jm0204587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12723947-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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