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Article

3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase.

Journal of medicinal chemistry - 14 Apr 2011

Tang Jing, Maddali Kasthuraiah, Metifiot Mathieu, Sham Yuk Y, Vince Robert, Pommier Yves, Wang Zhengqiang

Abstract excerpt

Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). Inhibitors with a novel structure core are essential for combating resistance associated with known IN inhibitors (INIs). We have previously disclosed a novel dual inhibitor scaffold of HIV IN and reverse transcriptase (RT). Here we report the complete structure-activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21381765
DOI: 10.1021/jm1014378
PMCID: PMC3072462

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