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Article

A potent and orally active HIV-1 integrase inhibitor.

Bioorganic & medicinal chemistry letters - 1 Mar 2007

Egbertson Melissa S, Moritz H Marie, Melamed Jeffrey Y, Han Wei, Perlow Debra S, Kuo Michelle S, Embrey Mark, Vacca Joseph P, Zrada Matthew M, Cortes Amanda R, Wallace Audrey, Leonard Yvonne, Hazuda Daria J, Miller Michael D, Felock Peter J, Stillmock Kara A, Witmer Marc V, Schleif William, Gabryelski Lori J, Moyer Gregory, Ellis Joan D, Jin Lixia, Xu Wei, Braun Matthew P, Kassahun Kellem, Tsou Nancy N, Young Steven D

Abstract excerpt

A 1,6-naphthyridine inhibitor of HIV-1 integrase has been discovered with excellent inhibitory activity in cells, good pharmacokinetics, and an excellent ability to inhibit virus with mutant enzyme.

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17194584
DOI: 10.1016/j.bmcl.2006.11.080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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