Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Current and Novel Inhibitors of HIV Protease

11 Dec 2009

Abstract excerpt

The design, development and clinical success of HIV protease inhibitors represent one of the most remarkable achievements of molecular medicine. This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21994591
DOI: 10.3390/v1031209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Current and Novel Inhibitors of HIV ProteasePMID 21994591Read ↗

Comprehending the Structure, Dynamics, and Mechanism of Action of Drug-Resistant HIV ProteaseSemantic proximity Read ↗

HIV Protease: Historical Perspective and Current ResearchSemantic proximity Read ↗

Recent developments in HIV protease inhibitor therapy.Semantic proximity Read ↗

Design of novel HIV-1 protease inhibitors with favorable oral properties using a virtual screening and lead optimization approachSemantic proximity Read ↗

Development of Anti-HIV Therapeutics: From Conventional Drug Discovery to Cutting-Edge TechnologySemantic proximity Read ↗

HIV-1 protease inhibitors: effects on HIV-2 replication and resistanceSemantic proximity Read ↗

Pharmacokinetic Parameters of HIV-1 Protease Inhibitors.Semantic proximity Read ↗

HIV-1 integrase strand transfer inhibitors: a review of current drugs, recent advances and drug resistanceSemantic proximity Read ↗

Pharmacological advances in anti‐retroviral therapy for human immunodeficiency virus‐1 infection: A comprehensive reviewSemantic proximity Read ↗

Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.Semantic proximity Read ↗

Molecular docking-based screening for novel inhibitors of the human immunodeficiency virus type 1 protease that effectively reduce the viral replication in human cellsSemantic proximity Read ↗

“Old Dogs with New Tricks”: exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.