Article
Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate.
Journal of medicinal chemistry - 12 Dec 2019
Ramdas Vidya, Talwar Rashmi, Banerjee Moloy, Joshi Advait Arun, Das Amit Kumar, Walke Deepak Sahebrao, Borhade Prashant, Dhayagude Usha, Loriya Rajesh, Gote Ganesh, Bommakanti Apparao, Sivaram Aruna, Agarwal Gautam, Goswami Arnab, Nigade Prashant, Mehta Maneesh, Patil Vinod, Modi Dipak, Kumar Hemant, Mallurwar Sadanand, Dash Amruta, Modi Falguni, Kuldharan Sandip, Srivastava Pratima, Singh Minakshi, Narasimham Lakshmi, Gundu Jayasagar, Sharma Sharad, Kamboj Rajender Kumar, Palle Venkata P
Abstract excerpt
The identification of a novel class of potent pan-genotypic NS5A inhibitors with good pharmacokinetic profile suitable for potential use in treating HCV infections is disclosed here. The present series of compounds are with less complex tricyclic central core, identified through a systematic SAR study carried out on biphenyl moiety. The SAR outcome has confirmed the requirement of near planar and linear...
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