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Article

A herpes simplex virus type 1 mutant with gamma 34.5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice.

Neurosurgery - 1 Mar 2002

Samoto Ken, Ehtesham Moneeb, Perng Guey-Chuen, Hashizume Kazuhiro, Wechsler Steven L, Nesburn Anthony B, Black Keith L, Yu John S

Abstract excerpt

OBJECTIVE: We previously constructed a novel recombinant herpes simplex virus with deletions in the gamma 34.5 and LAT genes. LAT was replaced by the gene for green fluorescent protein, to allow monitoring of viral transduction in vitro and in vivo. We previously confirmed that this virus, designated DM33, retains its oncolytic properties in vitro and is inhibited with respect to spontaneous reactivation. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 11841729
DOI: 10.1097/00006123-200203000-00031

Genes

LAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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