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Article

Effect of γ34.5 deletions on oncolytic herpes simplex virus activity in brain tumors.

Journal of virology - 1 Apr 2012

Kanai Ryuichi, Zaupa Cecile, Sgubin Donatella, Antoszczyk Slawomir J, Martuza Robert L, Wakimoto Hiroaki, Rabkin Samuel D

Abstract excerpt

The ICP34.5 protein of herpes simplex virus (HSV) is involved in many aspects of viral pathogenesis; promoting neurovirulence, inhibiting interferon-induced shutoff of protein synthesis, interacting with PCNA and TBK1, inhibiting dendritic cell (DC) maturation, and binding to Beclin 1 to interfere with autophagy. Because of its key role in neuropathogenicity, the γ34.5 gene is deleted in all oncolytic HSVs...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22345479
DOI: 10.1128/JVI.00017-12
PMCID: PMC3318611

Genes

PCNA
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effect of γ34.5 deletions on oncolytic herpes simplex virus activity in brain tumors.PMID 22345479Read ↗

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