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Article

Oncolytic herpes simplex virus vectors for cancer virotherapy.

Cancer gene therapy - 1 Dec 2002

Varghese Susan, Rabkin Samuel D

Abstract excerpt

Oncolytic herpes simplex virus type 1 (HSV-1) vectors are emerging as an effective and powerful therapeutic approach for cancer. Replication-competent HSV-1 vectors with mutations in genes that affect viral replication, neuropathogenicity, and immune evasiveness have been developed and tested for their safety and efficacy in a variety of mouse models. Evidence to-date following administration into the brain...

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PMID: 12522436
DOI: 10.1038/sj.cgt.7700537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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