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Article

Active immunotherapy: oncolytic virus therapy using HSV-1.

Advances in experimental medicine and biology - 1 Jan 2012

Todo Tomoki

Abstract excerpt

Conditionally replicating herpes simplex viruses Type 1 (HSV-1) are promising therapeutic agents for glioma. They can replicate in situ, spread and exhibit oncolytic activity via a direct cytocidal effect. In addition, specific antitumor immunity is effectively induced in the course of oncolytic activities. G47Δ is a genetically engineered HSV-1 with triple mutations that realized augmented viral replication in...

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PMID: 22639168
DOI: 10.1007/978-1-4614-3146-6_14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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