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Article

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

10 May 1991

Abstract excerpt

Malignant gliomas are the most common malignant brain tumors and are almost always fatal. A thymidine kinase-negative mutant of herpes simplex virus-1 (dlsptk) that is attenuated for neurovirulence was tested as a possible treatment for gliomas. In cell culture, dlsptk killed two long-term human glioma lines and three short-term human glioma cell populations. In nude mice with implanted subcutaneous and subrenal...

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PMID: 1851332
DOI: 10.1126/science.1851332

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