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Oncolytic virus therapy using genetically engineered herpes simplex viruses

1 Nov 2007

Abstract excerpt

Genetically engineered, conditionally replicating herpes simplex viruses type 1 (HSV-1) are promising therapeutic agents for cancer. They can replicate in situ, spread, and exhibit oncolytic activity via a direct cytocidal effect. In addition, oncolytic HSV-1 can transfer and express foreign genes in host cells. The phase I clinical study with G207, a double-mutated HSV-1, in recurrent malignant glioma patients...

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PMID: 17981691
DOI: 10.2741/2823

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