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Article

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.

Molecular and cellular biology - 1 Jan 2002

Dan Chuntao, Nath Niharika, Liberto Muriel, Minden Audrey

Abstract excerpt

We have characterized a new member of the mammalian PAK family of serine/threonine kinases, PAK5, which is a novel target of the Rho GTPases Cdc42 and Rac. The kinase domain and GTPase-binding domain (GBD) of PAK5 are most closely related in sequence to those of mammalian PAK4. Outside of these domains, however, PAK5 is completely different in sequence from any known mammalian proteins. PAK5 does share...

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Source

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Identifiers

PMID: 11756552
DOI: 10.1128/MCB.22.2.567-577.2002
PMCID: PMC139731

Genes

PAK5
PAK1
PAK4

Variants

Provenance

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Related research

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Research trail→

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.PMID 11756552Read ↗

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The p21-activated kinases in neural cytoskeletal remodeling and related neurological disordersSemantic proximity Read ↗

Rac GTPases control axon growth, guidance and branching.Semantic proximity Read ↗

Mbt, a Drosophila PAK protein, combines with Cdc42 to regulate photoreceptor cell morphogenesis.Semantic proximity Read ↗

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