Article
[The relationship of p53 gene mutation to cell differentiation and metastasis of laryngeal squamous cell carcinoma].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Feb 2002
Zhang Xiaoqing, Wang Lihong, Liu Shixi, Ouyang Xuesong, Liang Chuanyu
Abstract excerpt
OBJECTIVE: To inquire about the relationship of p53 gene mutation to the histopathological findings and clinical manifestation in cases of laryngeal squamous cell carcinoma(LSCC). METHODS: The fresh samples from 60 cases of LSCC were examined. Polymerase chain reaction and silver staining-single strand conformation polymorphism (PCR-SSCP) and DNA direct sequencing were used to detect the mutation of p53 gene in...
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