Article
Low incidence of p53 mutations in well-differentiated tongue squamous cell carcinoma in Japan.
Japanese journal of clinical oncology - 1 Sept 2002
Tsurusako Shin-Ichi, Tanaka Hisashi, Hayashi Yasushi, Tohnai Iwai, Ueda Minoru, Ishizaki Kanji
Abstract excerpt
BACKGROUND: Despite an increasing number of patients suffering from squamous cell carcinomas of the tongue, little is known about the molecular mechanisms involved in the origin and development of these neoplasms. METHODS: We screened microdissected tongue squamous cell carcinoma (TSC) specimens from 28 consecutive, previously untreated, Japanese patients for mutations in the p53 tumor-suppressor gene...
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