Article
[Alteration of P53 protein expression and p53 gene in laryngeal carcinoma].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences - 1 Jun 2003
Zhu Ming, Lin Shan, Li Jun
Abstract excerpt
OBJECTIVE: To study the prevalence of P53 protein expression and p53 gene mutation in laryngeal carcinoma. METHODS: Using immunohistochemistry P53 expression was detected in 31 patients with laryngeal carcinoma. In 11 P53 negative patients,microdissection-PCR-HA technique was used to determine mutation in p53 exon 5, 6, 7, 8. RESULTS: Among the 31 patients tested with immunostaining, the overall average positive...
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