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Article

Quadruple-allele dipstick test for simultaneous visual genotyping of A896G (Asp299Gly) and C1196T (Thr399Ile) polymorphisms in the toll-like receptor-4 gene.

Clinica chimica acta; international journal of clinical chemistry - 9 Oct 2011

Litos Ioannis K, Ioannou Penelope C, Christopoulos Theodore K, Tzetis Maria, Kanavakis Emmanuel, Traeger-Synodinos Jan

Abstract excerpt

BACKGROUND: Toll-like receptor-4 (TLR4) is a central regulators of innate immune response as it interacts with bacterial lipopolysaccharide (LPS) and also with endogenous molecules, such as heat-shock proteins and fibrinogen. Two common single nucleotide polymorphisms, A896G (Asp299Gly) and C1196T (Thr399Ile), have been found in the exon 3 of human TLR4 gene, which lead to structure alteration of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21763687
DOI: 10.1016/j.cca.2011.07.001

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TLR4

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