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Article

A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy.

Annals of neurology - 1 Feb 2002

Stögmann Elisabeth, Zimprich Alexander, Baumgartner Christoph, Aull-Watschinger Susanne, Höllt Volker, Zimprich Fritz

Abstract excerpt

The prodynorphin gene (PDYN) encoding the anticonvulsant peptide dynorphin is a strong candidate for a seizure suppressor gene and thus a possible modulator of susceptibility to temporal lobe epilepsy. We performed a case control association study in 155 patients with nonlesional temporal lobe epilepsy and 202 controls and found that PDYN promotor low-expression L-alleles confer an increased risk for temporal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11835385
DOI: 10.1002/ana.10108

Genes

PDYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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