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Article

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model.

Journal of pharmaceutical sciences - 1 Feb 2002

Pepinsky R Blake, Shapiro Renee I, Wang Shaoshan, Chakraborty Abhijit, Gill Alan, Lepage Doreen J, Wen Dingyi, Rayhorn Paul, Horan Gerald S B, Taylor Frederick R, Garber Ellen A, Galdes Alphonse, Engber Thomas M

Abstract excerpt

The therapeutic effects of the Sonic hedgehog (Shh) have been difficult to evaluate because of its relatively short serum half-life. To address this issue polyethylene glycol modification (PEGylation) was investigated as an approach to improve systemic exposure. Shh was PEGylated by a targeted approach using cysteines that were engineered into the protein by site-directed mutagenesis as the sites of attachment....

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PMID: 11835197
DOI: 10.1002/jps.10052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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