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Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention

1 Mar 2024

Abstract excerpt

Hedgehog (Hh) signaling plays a significant role in embryogenesis and several physiological processes, such as wound healing and organ homeostasis. In a pathological setting, it is associated with oncogenesis and is responsible for disease progression and poor clinical outcomes. Hedgehog signaling mediates downstream actions via Glioma Associated Oncogene Homolog (GLI) transcription factors. Inhibiting Hh...

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PMID: 38432565
DOI: 10.1016/j.abb.2024.109952

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