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Article

Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses.

Nature neuroscience - 1 Apr 2009

Chan Jennifer A, Balasubramanian Srividya, Witt Rochelle M, Nazemi Kellie J, Choi Yoojin, Pazyra-Murphy Maria F, Walsh Carolyn O, Thompson Margaret, Segal Rosalind A

Abstract excerpt

Sonic Hedgehog (Shh) has dual roles in vertebrate development, promoting progenitor cell proliferation and inducing tissue patterning. We found that the mitogenic and patterning functions of Shh can be uncoupled from one another. Using a genetic approach to selectively inhibit Shh-proteoglycan interactions in a mouse model, we found that binding of Shh to proteoglycans was required for proliferation of neural...

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Identifiers

PMID: 19287388
DOI: 10.1038/nn.2287
PMCID: PMC2676236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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